By: Chioma Umeha
…Affects blood vessels, kidneys, brain, others
Physicians have provided evidence that even in the absence of increase in blood pressure, excess dietary sodium can adversely affect target organs, including the blood vessels, heart, kidneys and the brain.
Sodium is essential for fluid balance and cellular homeostasis, or maintenance of a stable internal environment in an organism. But the amount of salt needed to maintain homeostasis in adults is quite low – about 500 milligrams (mg) per day.
On the contrary, many consume more than six times that much, which leads to high blood pressure in many people.New research has suggested that not everyone can eat salty snacks and convenience foods without having low blood pressure. A review paper co-authored by two faculty members in the University of Delaware College of Health Sciences and two physicians at the Christiana Care Health System provides evidence that even in the absence of an increase in blood pressure, excess dietary sodium can adversely affect target organs, including the blood vessels, heart, kidneys and the brain.
Authors of the paper, ‘Dietary Sodium and Health: More Than Just Blood Pressure,’ include William Farquhar and David Edwards in UD’s Department of Kinesiology and Applied Physiology; William Weintraub, chief of cardiology at Christiana Care; and Claudine Jurkovitz, a nephrologist epidemiologist and senior scientist in the Value Institute Center for Outcomes Research at Christiana Care. The paper was published in the March 17 issue of the Journal of the American College of Cardiology. “Blood pressure responses to alterations in dietary sodium vary widely, which has led to the concept of ‘salt-sensitive’ blood pressure,” said Farquhar. “There are no standardized guidelines for classifying individuals as having salt-sensitive blood pressure, but if blood pressure increases during a period of high dietary sodium or decreases during a low-sodium period, the person is considered salt sensitive. If there is no change in blood pressure with sodium restriction, an individual is considered salt resistant.”
However, the research cited in the paper showed that there were adverse effects on multiple target organs and tissues, even for people who are salt resistant. Potential effects on the arteries include reduced function of the endothelium, which is the inner lining of blood vessels. Endothelial cells mediate a number of processes, including coagulation, platelet adhesion and immune function. Elevated dietary sodium can also increase arterial stiffness. Farquhar and Edwards have done previous work in this area, with one study showing that excess salt intake in humans impairs endothelium-dependent dilation and another demonstrating that dietary sodium loading impairs microvascular function. In both cases, the effects are independent of changes in blood pressure.
They review their work and the growing body of evidence to support a deleterious effect of dietary salt on vascular function independent of blood pressure in a recent invited paper in Current Opinion in Nephrology and Hypertension. “High dietary sodium can also lead to left ventricular hypertrophy, or enlargement of the muscle tissue that makes up the wall of the heart’s main pumping chamber,” Edwards said: “As the walls of the chamber grow thicker, they become less compliant and eventually are unable to pump as forcefully as a healthy heart.” Regarding the kidneys, evidence suggests that high sodium is associated with reduced renal function, a decline observed with only a minimal increase in blood pressure.
Finally, sodium may also affect the sympathetic nervous system, which activates what is often termed the fight-or-flight response. “Chronically elevated dietary sodium may ‘sensitize’ sympathetic neurons in the brain, causing a greater response to a variety of stimuli, including skeletal muscle contraction,” Farquhar said: “Again, even if blood pressure isn’t increased, chronically increased sympathetic outflow may have harmful effects on target organs.” Jurkovitz pointed out that studying the effects of salt restriction on clinical outcomes is not easy. Challenges include accurate assessment of intake, long-term maintenance on a defined salt regimen, and the need for large numbers of patients and extended follow-up to obtain enough outcomes for meaningful analysis.
However, she said: “A large body of evidence confirms the biological plausibility of the association between high sodium intake and increases in blood pressure and cardiovascular events.” This evidence has resulted in the American Heart Association’s recommendation that we consume less than 1,500 mg of sodium a day.
Taking the salt shaker off the table is a good way to start, but it is probably not enough, said Weintraub, whose work focuses on cardiology outcomes. “Approximately 70 per cent of the sodium in our diets comes from processed foods, including items that we do not typically think of as salty such as breads and cereals,” he said. “Also, restaurant food typically contains more salt than dishes prepared at home, so eating out less can help reduce salt intake, especially if herbs and spices – instead of salt- are used to add flavour to home-cooked meals.” But the authors acknowledge that shaking the salt habit would be easy, and it won’t happen overnight.
“Reducing sodium will take a coordinated effort involving organizations like the AHA, food producers and processors, restaurants, and public policy aimed at education,” Weintraub said.
This story was published in Newswatch Times on March 14, 2015.